Education
Umass Amherst Biology, BS
Umass Dartmouth Biomedical Engineering, MS
The succinimidyl valerate is an active ester used for the PEGylation of primary amines. The reaction of the SVA with an amine forms a stable amide linkage. This reaction may be performed in an organic solution with a base catalyst or may be performed in an aqueous solution at a pH range of 8 to 9. The reaction should be allowed to mix for a minimum of 4 hours. By tailoring the pH of a reaction, the selectivity for the PEGylation of a specific site is increased.
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